Clinical Cognitive Neuroscience Center



Magnetic Resonance Imaging (MRI)

Structure and Function of The Brain in Psychiatric Disorders

Structure of The Brain

Function of The Brain

(A) For within‐group maps with each subdivision, green represents regions showing significant functional connectivity in controls; red in patients; and yellow represents the spatial overlap between two groups.
(B) For between‐group comparison maps, green represents regions where functional connectivity was decreased in patients, while red represents regions where connectivity was increased in patients.

Hwang et al. (2017), Human Brain Mapping.

Microstructural Changes in The Brain: Diffusion Kurtosis Imaging (DKI)

The microstructural complexity investigated with mean kurtosis values. Free water has a Gaussian distribution of the displacement profile, which makes the kurtosis value zero. However, as brain tissues develops, thus increasingly occupying space and hindering diffusion, the diffusion profile becomes more complicated and deviates from the Gaussian distribution. This results in increased kurtosis values.

Visualization of the thalamic regions with strong connections to the orbitofrontal and lateral temporal cortices

Cho et al. (2018), Biological Psychiatry. 

Positron Emission Tomography (PET)

Psychopharmacological Treatment for Schizophrenia and OCD

The relationship between dopamine receptor blockade and cognitive performance in schizophrenia

The relationship between dopamine D2/3 receptor occupancy and mean error rates in the no-memory load and memory-load conditions of the N-back task after aripiprazole administration.

Shin et al. (2018), Translational Psychiatry