Clinical Cognitive Neuroscience Center

Research

Electrophysiology

EEG / ERP

Electroencephalography / Event-Related Potentials

  • MMN Mismatch negativity

    Sensory learning & perceptual accuracy (typically automatic changes in auditory stimuli)

  • P300​ Positive deflection of ERP

    Oddball paradigm: decision making

  • LPP Late positive potential

    The emotional intensity of fa stimulus

  • Others Resting-state EEG Error-related negativity Correct response negativity N2 (or N200)
Mismatch Negativity(MMN) Sensory learning & perceptual accuracy (typically automatic changes in auditory stimuli)
Predicting Remission in Subjects at Clinical High Risk for Psychosis Using Mismatch Negativity

MMN is a putative predictor of prognosis regardless of the transition to psychotic disorder in subjects at clinical-high risk (CHR).

Kim et al. (2018), Schizophrenia Bulletin
P300 Positive deflection of ERP. Oddball paradigm: decision making
Decomposing P300 into correlates of genetic risk and current symptoms in schizophrenia: An inter-trial variability analysis

P300 amplitude is an endophenotype for schizophrenia and that greater inter-trial variability of P300 is associated with more severe negative and cognitive symptoms in schizophrenia patients.

Kim et al., 2018, Schizophrenia Research
Dysfunctional information processing during an auditory event-related potential task in individuals with Internet gaming disorder

The reduced amplitude of the P300 component in an auditory oddball task may reflect dysfunction in auditory information processing and cognitive capabilities in IGD.

Park et al. (2016), Translational Psychiatry
Late Positive Potential (LPP) Positive deflection of ERP. Oddball paradigm: decision making
Increased Attentional Bias Toward Visual Cues in Internet Gaming Disorder and Obsessive-Compulsive Disorder: An Event-Related Potential Study

Increased LPPs in response to disorder-specific cues (game-related and OCD-related) were found in both IGD and OCD groups respectively, although the groups showed overlapping arousal on subjective scales.

Kim et al., 2018, Frontiers in Psychiatry
Others Resting-state EEG; Error-related negativity; Correct response negativity N2 (or N200)
Prediction of individual responses to electroconvulsive therapy in patients with schizophrenia: Machine learning analysis of resting-state electroencephalography

The results of the current study suggest that higher effective connectivity in frontal areas may be associated with a favorable ECT response. Furthermore, personalized decisions to perform ECT in clinical practice could be augmented by resting-state EEG biomarkers of the ECT response in schizophrenia patients.

Kim et al. (2020), Schizophrenia Research
Neurophysiological correlates of altered response inhibition in internet gaming disorder and obsessive-compulsive disorder: Perspectives from impulsivity and compulsivity

Prolonged NoGo-N2 latency may serve as a marker of trait impulsivity in IGD and reduced NoGo-N2 amplitude may be a differential neurophysiological feature between OCD from IGD with regard to compulsivity.

Kim et al. (2017), Scientific Reports
Neurophysiological features of Internet gaming disorder and alcohol use disorder: a resting-state EEG study

Lower absolute beta power can be used as a potential trait marker of internet gaming disorder. Higher absolute power in the delta band may be a susceptibility marker for alcohol use disorder.

Son et al., 2015, Translational Psychiatry