Clinical Cognitive Neuroscience Center

Research

Electrophysiology

EEG / ERP

Electroencephalography / Event-Related Potentials

  • MMN Mismatch negativity

    Preattentive auditory processing

  • P300​ Auditory oddball paradigm

    Working memory update of change and Attention

  • LPP Late positive potential

    Emotional arousal to the stimuli

  • Others Resting-state EEG N2-P3 complex Error-related negativity
Mismatch Negativity(MMN) Preattentive auditory processing
Predicting Remission in Subjects at Clinical High Risk for Psychosis Using Mismatch Negativity

MMN is a putative predictor of prognosis regardless of the transition to psychotic disorder in subjects at clinical-high risk (CHR).

Kim et al. (2018), Schizophrenia Bulletin
P300 Auditory oddball paradigm; Working memory update of change and Attention
Decomposing P300 into correlates of genetic risk and current symptoms in schizophrenia: An inter-trial variability analysis

P300 amplitude is an endophenotype for schizophrenia and that greater inter-trial variability of P300 is associated with more severe negative and cognitive symptoms in schizophrenia patients.

Kim et al., 2018, Schizophrenia Research
Late Positive Potential (LPP) Emotional arousal to the stimuli
Neurophysiological correlate of emotion regulation by cognitive reappraisal and its association with psychotic symptoms in early psychosis

LPP modulation by cognitive reappraisal was negatively correlated with positive symptom severity in the FEP patients and with disorganization severity in the CHR subjects. Inefficient use of cognitive reappraisal may be related to the impaired emotion regulation and psychotic symptoms from the very beginning of psychotic disorder.

Kim et al. (2021), Schizophrenia Bulletin
Others Resting-state EEG; N2-P3 complex; Error-related negativity
Prediction of individual responses to electroconvulsive therapy in patients with schizophrenia: Machine learning analysis of resting-state electroencephalography

The results of the current study suggest that higher effective connectivity in frontal areas may be associated with a favorable ECT response. Furthermore, personalized decisions to perform ECT in clinical practice could be augmented by resting-state EEG biomarkers of the ECT response in schizophrenia patients.

Kim et al. (2020), Schizophrenia Research
Neurophysiological correlates of altered response inhibition in internet gaming disorder and obsessive-compulsive disorder: Perspectives from impulsivity and compulsivity

Prolonged NoGo-N2 latency may serve as a marker of trait impulsivity in IGD and reduced NoGo-N2 amplitude may be a differential neurophysiological feature between OCD from IGD with regard to compulsivity.

Kim et al. (2017), Scientific Reports
Impaired error-related processing in patients with first-episode psychosis and subjects at clinical high risk for psychosis: An event-related potential study

FEP patients and CHR subjects showed significantly smaller ERN amplitudes compared to HCs, indicating that performance monitoring is already compromised during the early course of psychotic disorders.

Park et al. (2021), Psychiatry and Clinical Neurosciences