Clinical Cognitive Neuroscience Center

Research

Neuropsychology

Neuropsychology

Working memory / Visual-Spatial Working Memory / Theory of Mind / Neurocognition in Mental Disorders

Working Memory

The ability to preserve information over short periods of time and to control this information for future use which also called as “short-term memory”
Tasks: ① Digit span (Blankenship, 1938) ② N-back task (Kirchner, W. K., 1958) ③ Own development task​

Changes in Effective Connectivity According to Working Memory Load: An fMRI Study of Face and Location Working Memory Tasks

Dynamic shift between the fast imagery circuit (right hemisphere) and the stable verbal circuit (left hemisphere), depending on task load.

Kim et al. (2012), Psychiatry investigation

Visual-Spatial Working Memory

A sub-category of working memory that manipulates especially the visual and spatial information stored in the brain to develop other information. This domain is associated with the capacity to recollect colors and shapes of somethings as well as their locations and movements
Tasks: ① Rey-Osterrieth complex figure test (ROCF, RCFT) ② Discrimination task ③ Arm maze task

Impaired body but not face perception in patients with obsessive–compulsive disorder

Patients with OCD experience difficulty in perceiving static forms of bodily postures.

Shin et al. (2012), Journal of neuropsychology

Theory of Mind (Mentalization)

Theory of mind ability is used to understand other people’s intent, emotions, desires and anticipate how that person will act. And that leads to our ability to interact fluently someone appropriate for social situations. We also research mentalization ins emotional domain as the ToM in cognitive domain.
Tasks: ① Story task ② RMET

Aberrant within- and between-network connectivity of the mirror neuron system network and the mentalizing network in first episode psychosis

Alterations in the integrity of the mirror neuron system network are highly related to deficient theory of mind in schizophrenia, and this problem would be present from the early stage of psychosis.

Choe et al. (2018), Schizophrenia Research

Neurocognition in Mental Disorders

Many psychiatric disorders have broad cognitive deficit respectively, but medication target symptoms yet and almost fail to increase cognitive ability. So, to gain effect of treatment targeting cognitive deficit, we must understand neurocognition map of overall psychiatric disorders. Also, they will be important components of pathophysiology of psychiatric disorders for approaching new nosology system.
Tasks: ① Story task ② RMET

Clinical and neurocognitive profiles of subjects at high risk for psychosis with and without obsessive–compulsive symptoms

The obsessive-compulsive symptoms manifested in UHR individuals was associated with a more severe clinical symptomatic presentation. On the other hand, those with UHR−OCS performed more poorly on some cognitive tests.​

Hur et al. (2012), Australian & New Zealand Journal of Psychiatry
Others : Kim et al. (2011), Schizophrenia Research; Jang et al. (2011), Australian & New Zealand Journal of Psychiatry; Shin et al. (2014), Psychological Medicine

Others

Perception and social behavior Biological Motion Perception, Brain Responses, and Schizotypal Personality Disorder

Individuals with SPD display heightened activation in the neural circuitry involved in reward and decision making when viewing biological motion stimuli (in addition to a positive correlation between increased blood oxygenation level–dependent signal responses related to biological motions and clinical symptoms.)​

Hur et al. (2016), JAMA Psychiatry
Others: Kim et al. (2011), Early intervention in psychiatry; Hur et al. (2015), Schizophrenia Research; Park et al. (2016), Prog Neuropsychopharmacol Biol Psychiatry
Verbal fluency

The cognitive ability to build and express words or sentence with required criteria. It’s essential to communicate others, eventually for various social functioning. It divides to (1) semantic fluency and (2) phonemic fluency.

Shin et al. (2012), Journal of Obsessive-Compulsive and Related Disorders
Executive function

A combination of various cognitive processes necessary for proper behavior. It includes other cognitive processes such as attention, inhibition, working memory, flexibility and so on. It also associated with planning and reasoning which is higher order cognitive processes.

Yun et al. (2017), Psychiatry investigation
Impulsivity

Although impulsivity has diverse domain, but that indicates tendency to act on impulse rather than thought. Impulsive actions are characterized by lack of careful consideration, risky action, improper response for specific situation. This characteristic is important component of various psychiatric disorders.

Lee et al. (2012), Cyberpsychology, Behavior, and Social Networking; Lee et al. (2013), Prog Neuropsychopharmacol Biol Psychiatry