Clinical Cognitive Neuroscience Center

Research

Clinical Trials

Clinical Trials

We take part in multicenter clinical trials of new and established treatments for schizophrenia at Seoul National University Hospital.

Ongoing

Switching to Aripiprazole Long-Acting Injection in Schizophrenia (Phase 4)

A 24-week, open-label, multicenter study of patients with schizophrenia who switch to aripiprazole once-monthly from oral antipsychotics or from other long-acting injections, examining changes in functioning, quality of life, symptoms, and sexual function.

Sponsor: Korea Otsuka Pharmaceutical

Completed

Long-Term Safety of Iclepertin (BI 425809) in Schizophrenia (Phase 3 Extension)

An open-label extension study evaluating the long-term safety of once-daily iclepertin in patients with schizophrenia who completed a previous phase 3 trial.

Sponsor: Boehringer Ingelheim

Iclepertin (BI 425809) for Cognitive Impairment in Schizophrenia (Phase 3)

A 26-week, randomized, double-blind, placebo-controlled trial of iclepertin, a glycine transporter 1 inhibitor, on cognition and functional capacity in patients with schizophrenia.

Sponsor: Boehringer Ingelheim

WID-RGC20 (Cariprazine) in Acute Schizophrenia (Phase 3)

A trial evaluating the efficacy and safety of WID-RGC20 at 3 mg/day and 6 mg/day in patients with schizophrenia experiencing an acute psychotic episode.

Sponsor: Whanin Pharmaceutical

MK-8189 in Acute Schizophrenia

A trial evaluating the efficacy and safety of MK-8189 in patients with an acute episode of schizophrenia.

Sponsor: MSD

Lurasidone versus Quetiapine XR in Acute Schizophrenia

A 6-week, randomized, double-blind, active-controlled trial testing the noninferiority of lurasidone to quetiapine XR in Korean patients with schizophrenia experiencing acute psychotic symptoms.

Sponsor: Bukwang Pharmaceutical

Results: Kim et al., Psychiatry Investig, 2024.

Switching from Oral Antipsychotics to Aripiprazole Once-Monthly (MAESTRO)

An open-label study evaluating the efficacy and safety of switching from oral atypical antipsychotics to aripiprazole once-monthly in patients with schizophrenia.

Sponsor: Korea Otsuka Pharmaceutical